Mechanisms of Response and Tolerance to Active RAS Inhibition in <i>KRAS</i> -Mutant Non–Small Cell Lung Cancer

🏆 Top 20📊 OpenAlex

Most Cited Paper

in Cancer-related Molecular Pathways

18 Months Post-Publication

Class of 2026

“Mechanisms of Response and Tolerance to Active RAS Inhibition in <i>KRAS</i> -Mutant Non–Small Cell Lung Cancer”

AuthorsHaniel A Araujo, Ximo Pechuan-Jorge, Teng Zhou et al.

Ferdinandos Skoulidis

JournalCancer Discovery

The University of Texas MD Anderson Cancer Center

Citations45

DOI10.1158/2159-8290.cd-24-0421

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Topics

RMC-7977 · RMC-7977 · KRASG12C-mutant NSCLC · inactive state-selective RASG12C inhibitors · RASGTP accumulation · active RAS inhibition · RASG12C(ON) inhibitor resistance · RASG12C(OFF) inhibitor resistance · single-cell transcriptional responses · mucinous transcriptional program · tumor cell persistence · sotorasib · adagrasib · mucinous histologic features · RAS pathway inhibition · covalent targeting of active RASG12C · reversible RASGTP inhibition · comutational models

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer-related Molecular Pathways Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-related-molecular-pathways/2026. Accessed 2026-10-24.

Methodology
Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459