Origins and impact of extrachromosomal DNA

🏆 Top 10📊 OpenAlex

Most Cited Paper

in Cancer Genomics and Diagnostics

18 Months Post-Publication

Class of 2026

“Origins and impact of extrachromosomal DNA”

AuthorsChris Bailey, Oriol Pich et al.

Paul S. Mischel, Mariam Jamal‐Hanjani, Charles Swanton

JournalNature

The Francis Crick Institute

Citations134

DOI10.1038/s41586-024-08107-3

A research intelligence initiative by Pepkio

pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026/

Topics

Extrachromosomal DNA · Extrachromosomal DNA · cancer · Gene amplification · Driver genes · immunomodulatory genes · inflammatory genes · lymphocyte-mediated immunity · immune effector processes · Immune cell infiltration · tissue-context-based selection · enhancers · promoters · lncRNA · ecDNA interactions in trans · Mutational processes · Tobacco exposure · homologous recombination deficiency · tumour stage · Targeted therapy · cytotoxic treatment · Metastasis · Overall survival · transcriptional landscape · Immunosuppression · tumour growth signals · 100,000 Genomes Project · Whole-genome sequencing · Gene amplification · ecDNA formation · ecDNA detection · Tumor heterogeneity · Genomic instability · Somatic mutations · Pan-cancer analysis · Tumor microenvironment · Gene amplification · structural variants · circular DNA · Cancer genomics

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026. Accessed 2026-07-13.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459