Tumour evolution and microenvironment interactions in 2D and 3D space

🏆 Top 10📊 OpenAlex

Most Cited Paper

in Cancer Genomics and Diagnostics

18 Months Post-Publication

Class of 2026

“Tumour evolution and microenvironment interactions in 2D and 3D space”

AuthorsChia-Kuei Mo, Jingxian Liu et al.

William E. Gillanders, Ryan C. Fields, Benjamin J. Raphael, Feng Chen, Li Ding

JournalNature

Washington University in St Louis

Citations127

DOI10.1038/s41586-024-08087-4

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Topics

Visium spatial transcriptomics · tumour microregions · spatial subclones · Single-nucleus RNA sequencing · CODEX · Copy number variation · Oncogenic activation · Immune cell infiltration · macrophage localization · 3D tumour reconstruction · serial section co-registration · immune hot neighbourhoods · immune cold neighbourhoods · immune exhaustion markers · antigen presentation · metabolic activity · tumour-stromal interactions · subclonal heterogeneity · unsupervised deep-learning · Tumor microenvironment

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026. Accessed 2026-08-20.

Methodology
Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459