Origins and impact of extrachromosomal DNA
Most Cited Paper
in Cancer Genomics and Diagnostics
18 Months Post-Publication
Class of 2026
“Origins and impact of extrachromosomal DNA”
A research intelligence initiative by Pepkio
pri.pepkio.com
Topics
Extrachromosomal DNA · 100,000 Genomes Project · Driver mutation · immunomodulatory gene amplification · lymphocyte-mediated immunity · Immune cell infiltration · enhancer-only ecDNA · promoter-only ecDNA · lncRNA elements · trans interactions between ecDNAs · Tobacco-induced mutagenesis · Homologous recombination deficiency · tissue-context-based selection · ecDNA in metastases · post-treatment ecDNA prevalence · ecDNA and overall survival · inflammatory gene amplification · ecDNA formation mechanisms · ecDNA progression mechanisms · combinatorial ecDNA effects
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026. Accessed 2026-08-20. Methodology Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459