Enhancing transcription–replication conflict targets ecDNA-positive cancers
Most Cited Paper
in Cancer Genomics and Diagnostics
18 Months Post-Publication
Class of 2026
“Enhancing transcription–replication conflict targets ecDNA-positive cancers”
A research intelligence initiative by Pepkio
pri.pepkio.com
Topics
Extrachromosomal DNA · Extrachromosomal DNA · transcription-replication conflict · single-stranded DNA · Replication stress · pRPA2-S33 · DNA double strand breaks · CHK1 · CHK1 inhibition · BBI-2779 · FGFR2 amplification · infigratinib · pan-FGFR inhibitor · gastric cancer · synthetic lethality · Acquired resistance · S-phase checkpoint · nucleotide incorporation · ecDNA-directed therapy
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026. Accessed 2026-08-20. Methodology Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459