Prognostic genome and transcriptome signatures in colorectal cancers

Topics

Colorectal cancer · Somatic mutations · Whole-genome sequencing · Transcriptomics · Driver genes · Population-based study · long-term follow-up · pathway co-mutations · mutation timing analysis · Mutational processes · Mutational signatures · Wnt/β-catenin pathway · EGFR pathway · TGFβ pathway · CYB gene · mitochondrial gene mutations · regulatory elements · Copy number variation · COSMIC SBS44 signature · survival analysis · gene expression classification · prognostic subtypes · microsatellite instability · hypoxia · Immune cell infiltration · stromal cell infiltration · Integrative genomic analysis · Prognosis · Personalized cancer therapy · primary colorectal tumors · cancer-causing mutations · Genomic alterations · Clinical outcome · expression subtypes · Tumor microenvironment