The genomic landscape of 2,023 colorectal cancers

🏆 Top 20📊 OpenAlex

Most Cited Paper

in Cancer Genomics and Diagnostics

18 Months Post-Publication

Class of 2026

“The genomic landscape of 2,023 colorectal cancers”

AuthorsAlex J. Cornish, Andreas Gruber, Ben Kinnersley, Daniel Chubb, Anna Frangou, Giulio Caravagna, Boris Noyvert, Eszter Lakatos, Henry M. Wood, S. Thorn, Richard Culliford et al.

Ian Tomlinson

JournalNature

Institute of Cancer Research

Citations118

DOI10.1038/s41586-024-07747-9

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pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026/

Topics

Colorectal cancer · Colorectal cancer · Whole-genome sequencing · Mutational landscape · Driver genes · microsatellite-stable CRC · microsatellite instability · chromosomal instability · 100,000 Genomes Project · molecular subgroups · prognostic associations · Mutational landscape · Escherichia coli pks+ · colibactin · rectal cancers · SBS93 mutational signature · diet as risk factor · Smoking · immune-escape driver mutations · Hypermutation · HLA copy number changes · BRCA1 · IDH1 · actionable mutations · Non-coding genome mutations · molecular pathways in CRC · Genomic landscape · Copy number variation · Mutational signatures · colorectum anatomical spectrum · rare molecular subgroups · patient care optimization · Driver genes · Somatic mutations · tumor genomics · Cancer genomics · APC · KRAS · TP53 · mismatch repair deficiency · Hypermutation · immune evasion · structural variants · indel signatures · cancer aetiology · Integrative genomic analysis

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Genomics and Diagnostics Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-genomics-and-diagnostics/2026. Accessed 2026-07-13.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459