Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer

Topics

TROP2 · antibody-drug conjugate · Pancreatic cancer · αTROP2-MMAE · MMAE · autophagy · caspase-9/PARP pathway · Apoptosis · autophagosomes · autophagic flux · PI3K/Akt/mTOR pathway · autophagy inhibitors · cytoprotective autophagy · BxPC3 cells · subcutaneous xenograft model · RNA sequencing · combination therapy

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026. Accessed 2026-10-24.

Methodology
Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459