THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer

🏆 Top 20📊 OpenAlex

Most Cited Paper

in Cancer Cells and Metastasis

18 Months Post-Publication

Class of 2026

“THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer”

AuthorsXing Zhou, Jiashu Han, Anning Zuo, Yuhao Ba, Shutong Liu et al.

Xinwei Han, Jinhai Deng, Zaoqu Liu

JournalMolecular Cancer

The First Affiliated Hospital of Zhengzhou University

Citations79

DOI10.1186/s12943-024-02180-y

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Topics

Matrix CAFs · COL8A1 · Therapy resistance · Epithelial-mesenchymal transition · PI3K/Akt/mTOR pathway · Colorectal cancer · ITGB1 receptor · Single-cell RNA sequencing · Spatial transcriptomics · Extracellular matrix remodeling · CAF heterogeneity · THBS2 · AKT inhibitor · ITGB1 knockdown · Therapy resistance · Tumor-stroma interactions · Tumor-stroma interactions

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Cancer Cells and Metastasis Papers, Class of 2026. https://pri.pepkio.com/top-papers/cancer-cells-and-metastasis/2026. Accessed 2026-10-24.

Methodology
Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459