Structure-guided discovery of ancestral CRISPR-Cas13 ribonucleases
Most Cited Paper
in Bacterial Genetics and Biotechnology
18 Months Post-Publication
Class of 2026
“Structure-guided discovery of ancestral CRISPR-Cas13 ribonucleases”
A research intelligence initiative by Pepkio
pri.pepkio.com
Topics
CRISPR-Cas13 · Cas13an · structural-search pipeline · ancestral clade identification · RNA-guided ribonuclease · programmable RNA depletion · Bacterial anti-phage defense systems · CRISPR RNA processing · RNA-guided nucleases · single active site dual activity · nuclease domain evolution · structure-guided genome mining · adaptive immunity in bacteria · defense-associated ribonucleases · precision RNA editing · heterologous RNA manipulation systems · Evolution of CRISPR-Cas · minimal Cas13 ortholog
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Bacterial Genetics and Biotechnology Papers, Class of 2026. https://pri.pepkio.com/top-papers/bacterial-genetics-and-biotechnology/2026. Accessed 2026-10-24. Methodology Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459