Phage-triggered reverse transcription assembles a toxic repetitive gene from a noncoding RNA

Topics

DRT2 defense system · reverse transcriptase · pseudoknotted noncoding RNA · tandem repeat synthesis · reconstituted promoter · toxic repetitive protein · Abortive infection · Bacterial anti-phage defense systems · Cryo-electron microscopy · biochemical reconstitution · reverse transcription in prokaryotes · antiviral defense mechanism · Noncoding RNA-templated DNA synthesis · template-directed repeat elongation · de novo open reading frame formation · RNA-guided protein synthesis · Bacterial innate immunity · retron-like defense system · Noncoding RNA-templated DNA synthesis · Bacterial anti-phage defense systems

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Bacterial Genetics and Biotechnology Papers, Class of 2026. https://pri.pepkio.com/top-papers/bacterial-genetics-and-biotechnology/2026. Accessed 2026-10-24.

Methodology
Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459