Topics and Trends in Most Cited Atrial Fibrillation Management and Outcomes Papers

Ranked by citations 18 months after publication

Class of 2026 (Papers Published in 2024)

What topics and trends defined most-cited Atrial Fibrillation Management and Outcomes research in the Class of 2026?

Pulsed field ablation, catheter ablation, pulmonary vein isolation, and CHA2DS2-VASc scoring anchor the Class of 2026 atrial fibrillation cohort. Incident atrial fibrillation, surgical ablation, and hybrid ablation rose sharply from Class of 2025, while paroxysmal AF, AF recurrence, and repeat-ablation themes receded among top-cited work.

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At a glance

Field
Atrial Fibrillation Management and Outcomes
Cohort label
Class of 2026 (2024 publications)
Papers analyzed
10,304
Papers ranked
20
Top topics in ranked papers
Pulsed field ablation, catheter ablation, pulmonary vein isolation, radiofrequency ablation, CHA2DS2-VASc score
Publication window
Jan 1, 2024 – Dec 31, 2024
Eligibility
Research articles; reviews excluded
Citation window
18 months post-publication
18m citation range
58–1,901
Data source
OpenAlex · Retrieved Jul 2026
License
CC BY 4.0

Rankings

20 papers ranked by 18-month citation count

#1 of 10,304
1,90118m citations

2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)

Isabelle C Van Gelder et al.European Heart Journal202410.1093/eurheartj/ehae176

CorrespondingIsabelle C Van GelderInstitution(Netherlands)., Netherlands

2024 ESC GuidelinesAtrial fibrillation managementEuropean Association for Cardio-Thoracic Surgery (EACTS)Stroke preventionOral anticoagulationCatheter ablationRate controlRhythm controlLeft atrial appendage occlusionCHA2DS2-VASc scoreDirect oral anticoagulantsAtrial fibrillation screeningRisk factor modificationIntegrated care pathwaySurgical ablationAtrial cardiomyopathyAntiarrhythmic drug therapyAtrial fibrillation recurrenceShared decision-making
#2 of 10,304
33118m citations

2024 European Heart Rhythm Association/Heart Rhythm Society/Asia Pacific Heart Rhythm Society/Latin American Heart Rhythm Society expert consensus statement on catheter and surgical ablation of atrial fibrillation

Stylianos Tzeis et al.EP Europace202410.1093/europace/euae043

CorrespondingStylianos TzeisInstitutionMitera Hospital, Greece

Catheter ablationSurgical ablationatrial fibrillationpulmonary vein isolationElectrophysiology procedureConsensus statementPatient selectionAblation technologyRhythm controlAF recurrence managementHybrid ablationCryoballoon ablationRadiofrequency ablationPulsed field ablationLeft atrial appendage occlusionAnticoagulation managementProcedural complicationsperiprocedural managementmultidisciplinary society collaborationAblation outcomes
#3 of 10,304
27918m citations

Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

Emmanuel Ekanem et al.Nature Medicine202410.1038/s41591-024-03114-3

CorrespondingEmmanuel EkanemInstitutionIcahn School of Medicine at Mount Sinai, United States

Pulsed field ablationatrial fibrillationPentaspline ablation catheterMANIFEST-17K studyPost-approval registry studyEsophageal injuryPulmonary vein stenosisPhrenic nerve injuryCardiac tamponadeVascular access complicationStrokeProcedural mortalityCoronary artery spasmHemolysis-related acute renal failureHemodialysisThermal ablation collateral damageparoxysmal atrial fibrillationPersistent atrial fibrillationMyocardial tissue selectivity
#4 of 10,304
18918m citations

Atrial fibrillation: epidemiology, screening and digital health

Dominik Linz et al.The Lancet Regional Health - Europe202410.1016/j.lanepe.2023.100786

CorrespondingDominik LinzInstitutionMaastricht University Medical Centre and Cardiovascular Research Institute Maastricht, Netherlands

atrial fibrillationLifetime risk of AFAtrial fibrillation prevalenceopportunistic screeningsystematic screeningDigital healthmHealthIntegrated care pathwaydigital screeningAtrial fibrillation complicationsAtrial fibrillation screeningAtrial fibrillation managementchronic disease care delivery models
#5 of 10,304
16518m citations

Atrial cardiomyopathy revisited—evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Society (APHRS), and the Latin American Heart Rhythm Society (LAHRS)

Andreas Goette et al.EP Europace202410.1093/europace/euae204

CorrespondingAndreas Goette, Luis Aguinaga, Takanori Yamaguchi, Stanley NattelInstitutionSt. Vincenz-Hospital Paderborn, Germany

Atrial cardiomyopathyAtCM staging systematrial fibrillation substrateatrial geometryelectrophysiological remodelingbiomarkers of atrial diseaseEHRA/HRS/APHRS/SOLAECE consensusConsensus statementAtCM-AF interrelationshipAtrial structural remodeling
#6 of 10,304
14918m citations

Left Atrial Appendage Closure after Ablation for Atrial Fibrillation

Oussama M Wazni et al.New England Journal of Medicine202410.1056/nejmoa2408308

CorrespondingOussama M WazniInstitutionCleveland Clinic, United States

Left atrial appendage occlusionOral anticoagulationCatheter ablationCHA2DS2-VASc scoreStroke risk assessmentThromboembolic eventsMajor bleedingclinically relevant nonmajor bleedingNoninferiority trialSuperiority testingProcedural complicationsOPTION trialBoston ScientificComposite end point of death, stroke, or embolismRandomized 1:1 assignment
#7 of 10,304
11818m citations

Asundexian versus Apixaban in Patients with Atrial Fibrillation

Jonathan P Piccini et al.New England Journal of Medicine202410.1056/nejmoa2407105

CorrespondingJonathan P PicciniInstitutionDuke Clinical Research Institute, United States

Factor XI inhibitionApixabanDirect oral anticoagulantsatrial fibrillationStroke preventionThromboembolic eventsMajor bleedingCHA2DS2-VASc scoreNoninferiority trialEarly trial terminationData and safety monitoring boardOCEANIC-AF trialphase 3 trialHazard ratioBleeding risk assessment
#8 of 10,304
10118m citations

Interpretable machine learning model for new-onset atrial fibrillation prediction in critically ill patients: a multi-center study

Chengjian Guan et al.Critical Care202410.1186/s13054-024-05138-0

CorrespondingJingchao Lu, Bing XiaoInstitutionThe Second Hospital of Hebei Medical University, China

Incident atrial fibrillationCritically ill patientsMIMIC-IV databaseMIMIC-III databaseLASSO regressionFeature selectionXGBoostSHapley Additive exPlanations (SHAP)Machine learning prediction modelexternal validationArea under the curveModel calibrationClinical decision support interfaceMechanical ventilationUrine outputSepsisBlood urea nitrogenPercutaneous arterial oxygen saturationContinuous renal replacement therapyRisk stratification threshold
#9 of 10,304
9018m citations

Pulsed Field Ablation to Treat Paroxysmal Atrial Fibrillation: Safety and Effectiveness in the AdmIRE Pivotal Trial

Vivek Y Reddy et al.Circulation202410.1161/circulationaha.124.070333

CorrespondingVivek Y ReddyInstitutionMount Sinai Fuster Heart Hospital, United States

Pulsed field ablationPentaspline ablation catheterElectroanatomic mappingBosense-Webster Irreversible Electroporation Ablation Systempulmonary vein isolationparoxysmal atrial fibrillationDrug-refractory atrial fibrillationAdmIRE pivotal trialNonfluoroscopic procedural guidanceLesion indexingTissue-to-catheter proximity feedbackProcedural complicationsCardiac tamponadeAtrial fibrillation recurrenceblanking periodClass I/III antiarrhythmic drugsElectrical cardioversionFluoroscopy exposure reductionQuality of life improvementInvestigational device exemption study
#10 of 10,304
8318m citations

Pulmonary Vein Isolation With Optimized Linear Ablation vs Pulmonary Vein Isolation Alone for Persistent AF

Caihua Sang et al.JAMA202410.1001/jama.2024.24438

CorrespondingChenxi Jiang, Chao Qiang Jiang, Chenyang Jiang, Changsheng MaInstitutionBeijing Anzhen Hospital, China

pulmonary vein isolationPersistent atrial fibrillationEthanol infusion of the vein of MarshallLinear ablationMitral isthmus ablationLeft atrial roof ablationCavotricuspid isthmus ablationRadiofrequency ablationSinus rhythm maintenancePROMPT-AF trialArrhythmia-free survivalAntiarrhythmic drug therapyAtrial tachycardiaAtrial flutterAtrial fibrillation burdenWearable single-lead ECG monitoringAmbulatory ECG monitoringMulticenter randomized trialFirst-time ablationQuality of life improvement
#11 of 10,304
7518m citations

Dual-energy lattice-tip ablation system for persistent atrial fibrillation: a randomized trial

Elad Anter et al.Nature Medicine202410.1038/s41591-024-03022-6

CorrespondingElad AnterInstitutionShamir Medical Center, Israel

Lattice tip catheterPersistent atrial fibrillationPulsed field ablationRadiofrequency ablationCatheter ablationwide-footprint lesion creationFocal radiofrequency ablationNoninferiority trialAtrial fibrillation recurrenceProcedural failureRepeat ablationblanking periodProcedural complicationsprocedural time reductionElectrical cardioversionAntiarrhythmic drug escalationlesion durabilityNCT05120193
#12 of 10,304
7518m citations

Atrial secondary tricuspid regurgitation: pathophysiology, definition, diagnosis, and treatment

Denisa Muraru et al.European Heart Journal202410.1093/eurheartj/ehae088

CorrespondingFabien PrazInstitutionUniversity of Milano-Bicocca, Italy

Atrial secondary tricuspid regurgitationRight atrial enlargementtricuspid annulus dilationleaflet malcoaptationatrial fibrillationHeart Failure With Preserved Ejection Fractiontricuspid valve leaflet tetheringventricular phenotypeatrial phenotypeMultimodality imagingRhythm controltricuspid valve interventionleaflet adaptive growthtricuspid regurgitation phenotyping
#13 of 10,304
7518m citations

Characterization and Clinical Significance of Hemolysis After Pulsed Field Ablation for Atrial Fibrillation: Results of a Multicenter Analysis

Miruna A Popa et al.Circulation Arrhythmia and Electrophysiology202410.1161/circep.124.012732

CorrespondingMiruna A PopaInstitutionDepartment of Cardiac Pacing and Electrophysiology, France

Pulsed field ablationCatheter ablationElectroporationErythrocyte susceptibility to electroporationPentaspline ablation catheterRadiofrequency ablationHemolysisHaptoglobinFree plasma hemoglobinBilirubinLactate dehydrogenaseHemoglobinuriapulmonary vein isolationparoxysmal atrial fibrillationPersistent atrial fibrillationRenal function biomarkersGlomerular filtration rateCreatinine increaseNumber of PFA deliveriesMulticenter analysis
#14 of 10,304
7418m citations

Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference

Dominik Linz et al.EP Europace202410.1093/europace/euae070

CorrespondingDominik LinzInstitutionMaastricht University Medical Center, Netherlands

Rhythm controlAtrial fibrillation burdenAtrial high-rate episodesStroke risk assessmentOral anticoagulationcardiovascular comorbiditiesmachine learning algorithms for AF detectionAtrial fibrillation complicationsRate controlbiomolecules for risk stratificationgenetics for risk stratificationcardiac imagingMajor bleedingAFNET/EHRA consensus conference
#15 of 10,304
7418m citations

Edoxaban Antithrombotic Therapy for Atrial Fibrillation and Stable Coronary Artery Disease

Min Soo Cho et al.New England Journal of Medicine202410.1056/nejmoa2407362

CorrespondingMin Soo ChoInstitutionAsan Medical Center, South Korea

Edoxaban monotherapyDual antithrombotic therapyatrial fibrillationStable coronary artery diseaseCHA2DS2-VASc scoreDirect oral anticoagulantsMajor bleedingclinically relevant nonmajor bleedingMyocardial infarctionThromboembolic eventsUnplanned urgent revascularizationComposite primary endpointAntithrombotic therapyEPIC-CAD trial
#16 of 10,304
6618m citations

Temporal trends in lifetime risks of atrial fibrillation and its complications between 2000 and 2022: Danish, nationwide, population based cohort study

Nicklas Vinter et al.BMJ202410.1136/bmj-2023-077209

CorrespondingNicklas VinterInstitutionAalborg University, Denmark

Lifetime risk of AFatrial fibrillation incidence trendsDanish national health registriesPopulation-based cohort studyheart failure as complication of atrial fibrillationStroke risk assessmentmyocardial infarction after atrial fibrillationSex differences in AFTemporal trends analysiscompeting risk analysisyears lost to heart failureIncident atrial fibrillationStroke preventionheart failure prevention strategiesnationwide registry dataAtrial fibrillation complications45 years and older populationcardiovascular complication burden
#17 of 10,304
6518m citations

Comparing CHA2DS2-VA and CHA2DS2-VASc scores for stroke risk stratification in patients with atrial fibrillation: a temporal trends analysis from the retrospective Finnish AntiCoagulation in Atrial Fibrillation (FinACAF) cohort

Konsta Teppo et al.The Lancet Regional Health - Europe202410.1016/j.lanepe.2024.100967

CorrespondingKonsta Teppo, Gregory Y.H. LipInstitutionTurku University Hospital and University of Turku, Finland

CHA2DS2-VASc scoreatrial fibrillationStroke risk assessmentFemale sex as stroke risk factorFinACAFNet reclassification improvementintegrated discrimination improvementC-statisticdecision curve analysisCox proportional hazards regressionTemporal trends analysisanticoagulant-naïve patientsIncident atrial fibrillationretrospective cohort studyrisk score recalibrationone-year stroke follow-uppopulation-based registry
#19 of 10,304
6018m citations

Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial

David J Werring et al.The Lancet202410.1016/s0140-6736(24)02197-4

CorrespondingDavid J. WerringInstitutionUniversity College London, United Kingdom

atrial fibrillationIschemic strokeDirect oral anticoagulantsAnticoagulation timingIntracranial hemorrhageThromboembolic eventsunclassifiable strokeStroke severityNoninferiority trialblinded-endpoint design90-day composite outcomemodified intention-to-treat analysis
Methodology

PRI identifies high-impact research using a transparent, topic-agnostic framework applied consistently across scientific domains. Bibliographic records are drawn from OpenAlex, including publication dates, citation relationships, and document types.

This ranking covers the Class of 2026 cohort: journal articles published in 2024. Reviews and other non-article document types are excluded to ensure comparability.

Research impact is quantified with an 18-month post-publication citation window—the number of citing works published within 18 months of each paper's publication date. This metric captures early impact while controlling for publication age.

An LLM-based relevance classifier then reviews each candidate's title and abstract to confirm substantive alignment with the target domain. Only papers classified as relevant appear in the final ranking.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459

Cite this ranking

Pepkio Research Index (PRI). Topics and Trends in Most Cited Atrial Fibrillation Management and Outcomes Papers, Class of 2026. https://pri.pepkio.com/top-papers/atrial-fibrillation-management-and-outcomes/2026. Accessed 2026-07-13.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459