Biguanide-Vancomycin Conjugates are Effective Broad-Spectrum Antibiotics against Actively Growing and Biofilm-Associated Gram-Positive and Gram-Negative ESKAPE Pathogens and Mycobacteria

Topics

biguanide-vancomycin conjugates · V–C6–Bg-PhCl (5e) · ESKAPE pathogens · vancomycin-resistant enterococcus · mycobacteria · Gram-negative bacteria · Gram-positive bacteria · biofilm-associated bacteria · cell wall synthesis inhibition · vancomycin binding sites · biguanide association with cell-surface anions · oritavancin · antibiotic-resistant infections · antibiotic-tolerant bacteria · biguanidinylation · vancomycin · broad-spectrum antibiotics · chronic infections