Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles

Topics

cerebrospinal fluid proteomics · mass spectrometry proteomics · Alzheimer's disease molecular subtypes · neuronal hyperplasticity · innate immune activation · RNA dysregulation · choroid plexus dysfunction · blood-brain barrier dysfunction · TREM2 R47H · AD genetic risk variants · brain atrophy anatomical patterns · Cerebrospinal fluid biomarkers · disease heterogeneity subtyping · personalized medicine in AD · 1058-protein panel

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Pepkio Research Index (PRI). Topics and Trends in Most Cited Alzheimer's disease research and treatments Papers, Class of 2026. https://pri.pepkio.com/top-papers/alzheimer-s-disease-research-and-treatments/2026. Accessed 2026-07-24.

Methodology
Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459