Lactylation‐Driven IGF2BP3‐Mediated Serine Metabolism Reprogramming and RNA m6A—Modification Promotes Lenvatinib Resistance in HCC
Most Cited Paper
in Epigenetics and DNA Methylation
18 Months Post-Publication
Class of 2026
“Lactylation‐Driven IGF2BP3‐Mediated Serine Metabolism Reprogramming and RNA m6A—Modification Promotes Lenvatinib Resistance in HCC”
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pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/
Topics
lenvatinib resistance · hepatocellular carcinoma · lysine lactylation · IGF2BP3 · PCK2 · NRF2 · serine metabolism reprogramming · N6-methyladenosine (m6A) modification · S-adenosylmethionine (SAM) · glycolysis · lactate accumulation · antioxidant defense system · RNA m6A methylation · lactylated IGF2BP3-PCK2-SAM-m6A loop · 2-Deoxy-D-glucose · siRNA targeting IGF2BP3 · liposome delivery · metabolic adaptation · epigenetic remodeling · molecular-targeted therapy resistance
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-20. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459