Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma
#3PRI RANKED
Most Cited Paper
in Epigenetics and DNA Methylation
18 Months Post-Publication
Class of 2026
“Positive feedback regulation between glycolysis and histone lactylation drives oncogenesis in pancreatic ductal adenocarcinoma”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/
Topics
histone lactylation · H3K18 lactylation · Pancreatic cancer · glycolysis · LDHA · LDHA · P300 · P300 · HDAC2 · TTK protein kinase · BUB1B · mitotic checkpoint regulators · CUT&Tag · LDHA Y239 phosphorylation · LDHA Y239 phosphorylation · positive feedback loop · Metabolic reprogramming · histone writers and erasers · lactate-dependent histone modification · glycolysis-H3K18la-TTK/BUB1B axis
Share
Cite this ranking
Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-20. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459