Mechanisms of action and resistance in histone methylation-targeted therapy
Most Cited Paper
in Epigenetics and DNA Methylation
18 Months Post-Publication
Class of 2026
“Mechanisms of action and resistance in histone methylation-targeted therapy”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/
Topics
H3K27me3 · EZH1-EZH2 dual inhibitor · valemetostat · adult T cell leukaemia/lymphoma · Chromatin condensation · PRC2 · integrative single-cell analyses · resistant clones · PRC2-compound interface mutations · TET2 mutation · DNMT3A expression · de novo DNA methylation · Chromatin condensation · H3K27me3-associated regions · epigenetic resistance mechanisms · tumour suppressor gene reactivation · primary susceptibility subpopulations · chromatin homeostasis · Epigenetic inheritance
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-20. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459