Histone H3K9 Lactylation Confers Temozolomide Resistance in Glioblastoma via LUC7L2‐Mediated MLH1 Intron Retention
Most Cited Paper
in Epigenetics and DNA Methylation
18 Months Post-Publication
Class of 2026
“Histone H3K9 Lactylation Confers Temozolomide Resistance in Glioblastoma via LUC7L2‐Mediated MLH1 Intron Retention”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/
Topics
histone H3K9 lactylation · temozolomide resistance · glioblastoma · LUC7L2 · MLH1 intron retention · mismatch repair · CUT&Tag · SLAM-seq · LDHA/B · stiripentol · recurrent glioblastoma · Post-translational modification · alternative splicing · epigenetic regulation · multi-omics analysis · blood-brain barrier penetration · Histone lactylation inhibition · combination therapy
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-20. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459