Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications
Most Cited Paper
in Epigenetics and DNA Methylation
18 Months Post-Publication
Class of 2026
“Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/
Topics
epigenome editing · Chromatin modification · H3K4me3 · H3K27me3 · H2AK119ub · single-cell transcriptional readouts · promoter targeting · Chromatin remodeling · DNA sequence motifs · cis-regulatory context · combinatorial modifications · silencing penetrance · modular platform · transcriptional instruction · context-dependent effects · switch-like regulation · attenuative regulation · Histone modification · causal perturbation · transcriptional heterogeneity
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-20. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459