Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation
Most Cited Paper
in Epigenetics and DNA Methylation
18 Months Post-Publication
Class of 2026
“Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/
Topics
glioblastoma · GBM stem cells · histone lactylation · lactate · CBX3 · CD47 · phagocytosis · microglia · macrophages · EP300 · histone acetyltransferase · lactyl-CoA · anti-CD47 therapy · immunosuppressive cytokine profile · Metabolic reprogramming · glycolysis · Immune evasion · epigenetic reprogramming · heterochromatin · tumor-associated macrophages
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-19. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459