Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
#1PRI RANKED
Most Cited Paper
in Epigenetics and DNA Methylation
18 Months Post-Publication
Class of 2026
“Genetic drivers of heterogeneity in type 2 diabetes pathophysiology”
A research intelligence initiative by Pepkio
pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026/
Topics
type 2 diabetes pathophysiology · multi-ancestry genome-wide association study · 1,289 independent association signals · 611 loci · eight non-overlapping clusters · cardiometabolic trait associations · cell-type-specific open chromatin · pancreatic islets · adipocytes · endothelial cells · enteroendocrine cells · cluster-specific partitioned polygenic scores · coronary artery disease · peripheral artery disease · end-stage diabetic nephropathy · obesity-related processes · single-cell epigenomics · aetiological heterogeneity · genetically informed diabetes care
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Pepkio Research Index (PRI). Topics and Trends in Most Cited Epigenetics and DNA Methylation Papers, Class of 2026. https://pri.pepkio.com/top-papers/epigenetics-and-dna-methylation/2026. Accessed 2026-07-20. Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459