# In vivo human T cell engineering with enveloped delivery vehicles

*PRI Rank #5 · Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 106 |
| Journal | Nature Biotechnology |
| Year | 2024 |
| DOI | 10.1038/s41587-023-02085-z |
| Corresponding authors | Jennifer A. Doudna |
| Institution | University of California, Berkeley, United States |

**Ranking page:** [Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026](https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026)

**Paper link:** [10.1038/s41587-023-02085-z](https://doi.org/10.1038/s41587-023-02085-z)

## Topics

enveloped delivery vehicles · Cas9-EDVs · antibody-targeted delivery · CRISPR-Cas9 protein delivery · guide RNA delivery · cell surface marker recognition · antibody fragments · membrane-derived particles · genome editing in vivo · Cell type-specific delivery · Adeno-Associated Virus · antibody-antigen interactions · Human T cells · CAR T-cell therapy · CAR-T cell generation · Humanized mice · Multiplexed Targeting · transient delivery · Ex Vivo Gene Transfer

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026. https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```