# Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo

*PRI Rank #4 · Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026/rank-4*

| Field | Value |
| --- | --- |
| Rank | #4 |
| 18m citations | 106 |
| Journal | Nature Biotechnology |
| Year | 2024 |
| DOI | 10.1038/s41587-023-02078-y |
| Corresponding authors | David R. Liu |
| Institution | Broad Institute of MIT and Harvard, United States |

**Ranking page:** [Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026](https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026)

**Paper link:** [10.1038/s41587-023-02078-y](https://doi.org/10.1038/s41587-023-02078-y)

## Topics

prime editing · engineered virus-like particles · PE-eVLP · Ribonucleoprotein complexes · prime editing guide RNAs · Nicking sgRNA · PE-eVLP · PE-eVLP · base editor eVLP · transient delivery · genetic blindness · retinal editing · visual function rescue · protein expression restoration · off-target editing reduction · transgene integration avoidance · In Vivo Delivery · genomic substitutions · insertions and deletions

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026. https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```