# Analytical characterization of full, intermediate, and empty AAV capsids

*PRI Rank #20 · Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026/rank-20*

| Field | Value |
| --- | --- |
| Rank | #20 |
| 18m citations | 36 |
| Journal | Gene Therapy |
| Year | 2024 |
| DOI | 10.1038/s41434-024-00444-2 |
| Corresponding authors | James B. McGivney |
| Institution | Oxford Biomedica (US) LLC, United States |

**Ranking page:** [Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026](https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026)

**Paper link:** [10.1038/s41434-024-00444-2](https://doi.org/10.1038/s41434-024-00444-2)

## Topics

Adeno-Associated Virus Vector · full capsids · intermediate capsids · empty capsids · capsid separation fractionation · cellular transduction competition · capsid load · vector genome titer · infectivity assays · gene expression assays · biological activity assays · in vivo potency assays · AAV product efficacy · AAV manufacturing impurities · potency as function of capsid content

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026. https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```