# Risk of Second Tumors and T-Cell Lymphoma after CAR T-Cell Therapy

*PRI Rank #2 · Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026/rank-2*

| Field | Value |
| --- | --- |
| Rank | #2 |
| 18m citations | 138 |
| Journal | New England Journal of Medicine |
| Year | 2024 |
| DOI | 10.1056/nejmoa2401361 |
| Corresponding authors | Mark P Hamilton |
| Institution | Stanford University, United States |

**Ranking page:** [Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026](https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026)

**Paper link:** [10.1056/nejmoa2401361](https://doi.org/10.1056/nejmoa2401361)

## Topics

CAR T-cell therapy · Secondary malignancies · T-cell lymphoma · Vector Genome Integration · Adoptive cell therapy · retroviral integration · clonal hematopoiesis · oncogenic integration · viral vector monitoring · clonal relationships · T-cell neoplasms · Secondary malignancies

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026. https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```