# Systematic multi-trait AAV capsid engineering for efficient gene delivery

*PRI Rank #18 · Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 38 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-50555-y |
| Corresponding authors | Fatma-Elzahraa Eid, Benjamin E. Deverman |
| Institution | Broad Institute of MIT and Harvard, United States |

**Ranking page:** [Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026](https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026)

**Paper link:** [10.1038/s41467-024-50555-y](https://doi.org/10.1038/s41467-024-50555-y)

## Topics

Fit4Function · Capsid Engineering · machine learning models · sequence-to-function models · Peptide-Modified Capsid · liver-targeted capsids · manufacturability · cross-species prediction · macaque biodistribution · human hepatocyte transduction · capsid library design · uniform sequence space sampling · multi-trait optimization · Adeno-Associated Virus Serotype 9 · production yields · murine liver transduction · in vivo screening · in vitro screening · gene therapy vectors · Adeno-Associated Virus

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026. https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```