# Chimeric Antigen Receptor T Cells Targeting CD19 and GCC in Metastatic Colorectal Cancer

*PRI Rank #15 · Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 44 |
| Journal | JAMA Oncology |
| Year | 2024 |
| DOI | 10.1001/jamaoncol.2024.3891 |
| Corresponding authors | Lei Xiao, Jiuwei Cui |
| Institution | the First Hospital of Jilin University, China |

**Ranking page:** [Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026](https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026)

**Paper link:** [10.1001/jamaoncol.2024.3891](https://doi.org/10.1001/jamaoncol.2024.3891)

## Topics

CAR T-cell therapy · CAR T-cell therapy · CD19 · Guanylate cyclase-C · Guanylate cyclase-C · GCC19 CART · metastatic colorectal cancer · autologous CAR T cells · Lentiviral Vector · cytokine release syndrome · objective response rate · progression-free survival · overall survival · partial response · refractory colorectal cancer · solid tumor immunotherapy · dual-target CAR T cells · Dose escalation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026. https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```