# Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects

*PRI Rank #14 · Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 44 |
| Journal | Signal Transduction and Targeted Therapy |
| Year | 2024 |
| DOI | 10.1038/s41392-024-01824-1 |
| Corresponding authors | Quan Yuan, Tianying Zhang, Ningshao Xia |
| Institution | Xiamen University, China |

**Ranking page:** [Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026](https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026)

**Paper link:** [10.1038/s41392-024-01824-1](https://doi.org/10.1038/s41392-024-01824-1)

## Topics

Oncolytic virus · rVSV-LCMVG · Adoptive cell therapy · mRNA vaccine · Combination therapy · tumor microenvironment · B16 tumor-bearing mice · CD8+ T cells · Neutralizing Antibodies · cytokine and chemokine levels · PD-1 down-regulation · Effector T-Cell Response · Intratumoral injection · Intravenous Administration · Tumor antigens · T-cell recruitment · immunosuppressive to immunosensitive transformation · refractory tumors · Immune cell infiltration

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026. https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```