# In vivo CAR T-cell generation in nonhuman primates using lentiviral vectors displaying a multidomain fusion ligand

*PRI Rank #13 · Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 45 |
| Journal | Blood |
| Year | 2024 |
| DOI | 10.1182/blood.2024024523 |
| Corresponding authors | Christopher J Nicolai |
| Institution | Umoja Biopharma, United States |

**Ranking page:** [Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026](https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026)

**Paper link:** [10.1182/blood.2024024523](https://doi.org/10.1182/blood.2024024523)

## Topics

CAR T-cell therapy · in vivo CAR T-cell generation · VivoVec platform · Lentiviral Vector · multidomain fusion protein · T-cell activation signals · costimulatory signals · VivoVec particles · Non-human primates · anti-CD20 CAR · B-cell depletion · in vivo transduction · lymphodepleting chemotherapy · B-cell malignancies

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026. https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```