# Expression of tumor antigens within an oncolytic virus enhances the anti-tumor T cell response

*PRI Rank #12 · Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 46 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-49286-x |
| Corresponding authors | Richard G. Vile |
| Institution | Mayo Clinic, United States |

**Ranking page:** [Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026](https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026)

**Paper link:** [10.1038/s41467-024-49286-x](https://doi.org/10.1038/s41467-024-49286-x)

## Topics

oncolytic vesicular stomatitis virus · VSV-IFNß · Immune checkpoint blockade · Immune checkpoint inhibitors · Liver cancer · tumor microenvironment · Effector T-Cell Response · T cell response · Cytometry by Time of Flight · tumor antigen expression · dominant anti-viral T cell responses · sub-dominant anti-tumor T cell responses · Oncolytic virotherapy · Immune checkpoint blockade · T cell recruitment and priming · Immune checkpoint inhibitor resistance · tumor antigen encoding

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026. https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```