# Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A

*PRI Rank #10 · Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026/rank-10*

| Field | Value |
| --- | --- |
| Rank | #10 |
| 18m citations | 51 |
| Journal | New England Journal of Medicine |
| Year | 2024 |
| DOI | 10.1056/nejmoa2410597 |
| Corresponding authors | Alok Srivastava |
| Institution | Christian Medical College Vellore, India |

**Ranking page:** [Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026](https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026)

**Paper link:** [10.1056/nejmoa2410597](https://doi.org/10.1056/nejmoa2410597)

## Topics

hemophilia A · lentiviral gene therapy · CD34+ hematopoietic stem cells · factor VIII expression · CD68 promoter · myeloid-directed expression · transduction enhancer · myeloablative conditioning · autologous HSC transplantation · Vector Copy Number · Factor VIII Activity · Annualized Bleeding Rate · Vector Copy Number · engraftment · neutropenia · thrombocytopenia · One-stage assay

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026. https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```