# AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial

*PRI Rank #1 · Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 189 |
| Journal | The Lancet |
| Year | 2024 |
| DOI | 10.1016/s0140-6736(23)02874-x |
| Corresponding authors | Yilai Shu |
| Institution | Fudan University, China |

**Ranking page:** [Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026](https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026)

**Paper link:** [10.1016/s0140-6736(23)02874-x](https://doi.org/10.1016/s0140-6736(23)02874-x)

## Topics

AAV1 vector · hOTOF gene · OTOFERLIN protein · DFNB9 · DFNB9 · gene therapy · single-arm trial · sensorineural hearing loss · inner ear gene delivery · cochlear hair cells · synaptic vesicle fusion · auditory synapse · hearing restoration

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Virus-based gene therapy research Papers, Class of 2026. https://pri.pepkio.com/top-papers/virus-based-gene-therapy-research/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```