# Autoantibodies neutralizing type I IFNs underlie severe tick-borne encephalitis in ∼10% of patients

*PRI Rank #3 · Topics and Trends in Most Cited Vector-borne infectious diseases Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/vector-borne-infectious-diseases/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 28 |
| Journal | The Journal of Experimental Medicine |
| Year | 2024 |
| DOI | 10.1084/jem.20240637 |
| Corresponding authors | Astrid Marchal, Andrea Fortova, Michaela Berankova, Alessandro Borghesi, Anne Puel, Paul Bastard, Aurélie Velay, Martin Martinot, Yves Hansmann, Judith H Aberle, Daniel Ruzek, Aurélie Cobat, Shen-Ying Zhang, Jean-Laurent Casanova |
| Institution | Institut National de la Santé et de la Recherche Médicale (INSERM), France |

**Ranking page:** [Topics and Trends in Most Cited Vector-borne infectious diseases Papers, Class of 2026](https://pri.pepkio.com/top-papers/vector-borne-infectious-diseases/2026)

**Paper link:** [10.1084/jem.20240637](https://doi.org/10.1084/jem.20240637)

## Topics

tick-borne encephalitis · tick-borne encephalitis virus · autoantibodies neutralizing type I interferons · IFN-α2 · IFN-β · IFN-ω · severe encephalitis · autoantibodies neutralizing type I interferons · Asymptomatic infection · odds ratios for severe TBE · 100 pg/ml IFN-α2 neutralization · 10 ng/ml IFN-α2 neutralization · hospitalized TBE patients · European TBE cohorts · Austria cohort · Czech Republic cohort · France cohort · type I IFN immunity · tick-borne transmission · TBE disease severity stratification

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Vector-borne infectious diseases Papers, Class of 2026. https://pri.pepkio.com/top-papers/vector-borne-infectious-diseases/2026. Accessed 2026-07-31.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```