# Exposure to Mycobacterium remodels alveolar macrophages and the early innate response to Mycobacterium tuberculosis infection

*PRI Rank #16 · Topics and Trends in Most Cited Tuberculosis Research and Epidemiology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/tuberculosis-research-and-epidemiology/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 34 |
| Journal | PLoS Pathogens |
| Year | 2024 |
| DOI | 10.1371/journal.ppat.1011871 |
| Corresponding authors | Dat Mai, Ana N. Jahn, Tara A. Murray, Michael Morikubo, Pamelia N. Lim, Maritza M. Cervantes, Linh K. Pham, Johannes Nemeth, Kevin B. Urdahl, Alan H. Diercks, Alan Aderem, Alissa C. Rothchild |
| Institution | Seattle Children's Research Institute, United States |

**Ranking page:** [Topics and Trends in Most Cited Tuberculosis Research and Epidemiology Papers, Class of 2026](https://pri.pepkio.com/top-papers/tuberculosis-research-and-epidemiology/2026)

**Paper link:** [10.1371/journal.ppat.1011871](https://doi.org/10.1371/journal.ppat.1011871)

## Topics

alveolar macrophages · Mycobacterium tuberculosis · subcutaneous BCG vaccination · Mycobacterium bovis · contained Mtb infection · concomitant immunity · interferon-associated response · Interferon Stimulated Genes · Single-cell RNA sequencing · airway-resident macrophages · innate cell activation · pro-inflammatory response · cell-intrinsic changes · lung microenvironment · ex vivo stimulation · Pam3Cys · LPS · macrophage remodeling · trained immunity · host-directed therapy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Tuberculosis Research and Epidemiology Papers, Class of 2026. https://pri.pepkio.com/top-papers/tuberculosis-research-and-epidemiology/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```