# CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection

*PRI Rank #15 · Topics and Trends in Most Cited Tuberculosis Research and Epidemiology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/tuberculosis-research-and-epidemiology/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 35 |
| Journal | Immunity |
| Year | 2024 |
| DOI | 10.1016/j.immuni.2024.08.002 |
| Corresponding authors | Sarah M. Fortune, Alex K. Shalek, JoAnne L. Flynn |
| Institution | Ragon Institute of MGH, MIT, and Harvard, United States |

**Ranking page:** [Topics and Trends in Most Cited Tuberculosis Research and Epidemiology Papers, Class of 2026](https://pri.pepkio.com/top-papers/tuberculosis-research-and-epidemiology/2026)

**Paper link:** [10.1016/j.immuni.2024.08.002](https://doi.org/10.1016/j.immuni.2024.08.002)

## Topics

Mycobacterium tuberculosis · Mtb reinfection · CD4+ T cell depletion · Non-human primate model · granuloma cellularity · immunological priming · protective immunity · CD8+ T cell reprogramming · neutrophilia · Type I interferon · myeloid cell modulation · lung microenvironment · immunomodulation · tuberculosis vaccine development · innate immune cell targeting

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Tuberculosis Research and Epidemiology Papers, Class of 2026. https://pri.pepkio.com/top-papers/tuberculosis-research-and-epidemiology/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```