# Tuberculosis in otherwise healthy adults with inherited TNF deficiency

*PRI Rank #12 · Topics and Trends in Most Cited Tuberculosis Research and Epidemiology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/tuberculosis-research-and-epidemiology/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 38 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07866-3 |
| Corresponding authors | Anna‐Lena Neehus, José Luis Franco, Jean‐Laurent Casanova |
| Institution | University of Antioquia UdeA, Colombia |

**Ranking page:** [Topics and Trends in Most Cited Tuberculosis Research and Epidemiology Papers, Class of 2026](https://pri.pepkio.com/top-papers/tuberculosis-research-and-epidemiology/2026)

**Paper link:** [10.1038/s41586-024-07866-3](https://doi.org/10.1038/s41586-024-07866-3)

## Topics

TNF deficiency · inherited loss-of-function TNF variant · Tuberculosis recurrence · Mycobacterium tuberculosis · IFNγ immunity · Bacillus Calmette–Guérin disease · Monocyte-derived macrophages · respiratory burst · GM-CSF-matured macrophages · alveolar macrophage-like cells · TNFR1 · Induced pluripotent stem cell-derived macrophages · TNF inhibitors · phagocyte oxidase deficiency · macrophage immunity · respiratory-burst-dependent immunity · weakly virulent mycobacteria

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Tuberculosis Research and Epidemiology Papers, Class of 2026. https://pri.pepkio.com/top-papers/tuberculosis-research-and-epidemiology/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```