# Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacy

*PRI Rank #6 · Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 110 |
| Journal | Cell |
| Year | 2024 |
| DOI | 10.1016/j.cell.2024.04.015 |
| Corresponding authors | Chen Wang, Christoph Scheiermann |
| Institution | University of Geneva, Switzerland |

**Ranking page:** [Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026](https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026)

**Paper link:** [10.1016/j.cell.2024.04.015](https://doi.org/10.1016/j.cell.2024.04.015)

## Topics

Circadian rhythm · CD8+ T cells · tumor infiltration · immunotherapy efficacy · Circadian rhythm · leukocyte infiltration · endothelial cells · Tumor microenvironment · CAR T cell therapy · Immune checkpoint blockade · time-of-day treatment · anti-PD-1 therapy · melanoma · time-of-day-dependent T cell signatures · overall survival prediction · Circadian rhythm

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026. https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```