# IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases

*PRI Rank #4 · Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026/rank-4*

| Field | Value |
| --- | --- |
| Rank | #4 |
| 18m citations | 125 |
| Journal | Nature Biotechnology |
| Year | 2024 |
| DOI | 10.1038/s41587-023-02060-8 |
| Corresponding authors | Li Tang |
| Institution | École Polytechnique Fédérale de Lausanne, Switzerland |

**Ranking page:** [Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026](https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026)

**Paper link:** [10.1038/s41587-023-02060-8](https://doi.org/10.1038/s41587-023-02060-8)

## Topics

IL-10-expressing CAR T cells · CAR T cell dysfunction resistance · solid tumor clearance · metastasis clearance · T cell exhaustion · CAR T cell therapy · cytokine engineering · Adoptive cell therapy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026. https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```