# Open-ST: High-resolution spatial transcriptomics in 3D

*PRI Rank #3 · Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 126 |
| Journal | Cell |
| Year | 2024 |
| DOI | 10.1016/j.cell.2024.05.055 |
| Corresponding authors | Giuseppe Macino, Nikos Karaiskos, Nikolaus Rajewsky |
| Institution | Max-Delbrück-Centrum for Molecular Medicine in the Helmholtz Association, Germany |

**Ranking page:** [Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026](https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026)

**Paper link:** [10.1016/j.cell.2024.05.055](https://doi.org/10.1016/j.cell.2024.05.055)

## Topics

Open-ST · Spatial transcriptomics · subcellular resolution · 3D reconstruction · mouse brain · head-and-neck tumors · metastatic lymph nodes · cell-cell communication hotspots · immune cell populations · stromal populations · tumor populations · Spatial transcriptomics · cell type reconstruction · cell states · Tumor microenvironment · 3D tumor boundary · Multimodal profiling · sequencing-based method · open-source protocols

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026. https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```