# The transcription factor ZEB2 drives the formation of age-associated B cells

*PRI Rank #20 · Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026/rank-20*

| Field | Value |
| --- | --- |
| Rank | #20 |
| 18m citations | 70 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adf8531 |
| Corresponding authors | Dai Dai, Shuangshuang Gu, Xiaxia Han, Carola G. Vinuesa, Nan Shen |
| Institution | Shanghai Institute of Rheumatology, China |

**Ranking page:** [Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026](https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026)

**Paper link:** [10.1126/science.adf8531](https://doi.org/10.1126/science.adf8531)

## Topics

Age-associated B cells · Age-associated B cells · ZEB2 · ZEB2 · transcription factor screen · ZEB2 haploinsufficiency · TLR7-driven lupus · toll-like receptor 7 · MEF2B · MEF2B · Mef2b intronic enhancer · germinal center B cell differentiation · Itgax · JAK-STAT pathway · JAK1/3 inhibitor · lupus pathogenesis · B cell autoimmunity · ABC specification

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026. https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```