# A spatial human thymus cell atlas mapped to a continuous tissue axis

*PRI Rank #19 · Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026/rank-19*

| Field | Value |
| --- | --- |
| Rank | #19 |
| 18m citations | 75 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07944-6 |
| Corresponding authors | Ronald N. Germain, Andrea J. Radtke, John C. Marioni, Tom Taghon, Sarah A. Teichmann |
| Institution | Wellcome Sanger Institute, United Kingdom |

**Ranking page:** [Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026](https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026)

**Paper link:** [10.1038/s41586-024-07944-6](https://doi.org/10.1038/s41586-024-07944-6)

## Topics

Cortico-Medullary Axis · Spatial transcriptomics · Multiplexed imaging · multimodal single-cell atlas · thymic involution · lobular cytokine network · thymocyte trajectories · thymic epithelial cell · Hassall's corpuscles · medullary entry timing · CD4 T cell lineage · CD8 T cell lineage · thymic epithelial cell progenitors · fetal thymus development · second trimester · TissueTag · OrganAxis construction · T lymphocyte development · spatially resolved analysis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026. https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```