# Programming tissue-sensing T cells that deliver therapies to the brain

*PRI Rank #18 · Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 76 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adl4237 |
| Corresponding authors | Milos Simic, Payal Watchmaker, Scott S. Zamvil, Hideho Okada, Wendell A. Lim |
| Institution | University of California San Francisco, United States |

**Ranking page:** [Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026](https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026)

**Paper link:** [10.1126/science.adl4237](https://doi.org/10.1126/science.adl4237)

## Topics

Synthetic Notch receptors · CNS-specific antigens · CNS extracellular matrix · tissue-sensing T cells · chimeric antigen receptor · brain tumor targeting · Interleukin-10 · neuroinflammation model · conditional payload expression · glial cell surface molecules · neuronal surface molecules · primary brain tumors · secondary brain tumors · anatomically targeted therapy · immunosuppressive cytokine delivery · cross-reactivity avoidance · engineered T cell programming

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026. https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```