# GLUT1 overexpression in CAR-T cells induces metabolic reprogramming and enhances potency

*PRI Rank #17 · Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026/rank-17*

| Field | Value |
| --- | --- |
| Rank | #17 |
| 18m citations | 76 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-52666-y |
| Corresponding authors | Elena Sotillo, Crystal L. Mackall |
| Institution | Stanford University, United States |

**Ranking page:** [Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026](https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026)

**Paper link:** [10.1038/s41467-024-52666-y](https://doi.org/10.1038/s41467-024-52666-y)

## Topics

GLUT1 overexpression · CAR T cells · Metabolic reprogramming · glucose consumption · Glycolysis · glycolytic reserve · oxidative phosphorylation · T cell exhaustion · Th17 differentiation · glutathione-mediated ROS resistance · inosine accumulation · proinflammatory cytokines · cytotoxicity · tumor control · CAR-T cell persistence · Tumor microenvironment · glucose availability · antitumor potency

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026. https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```