# PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells

*PRI Rank #15 · Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 93 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07254-x |
| Corresponding authors | Jan P. Böttcher |
| Institution | Technical University of Munich, Germany |

**Ranking page:** [Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026](https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026)

**Paper link:** [10.1038/s41586-024-07254-x](https://doi.org/10.1038/s41586-024-07254-x)

## Topics

Prostaglandin E2 · Precursor exhausted T cells · Tumor-infiltrating lymphocytes · EP2 receptor · EP4 receptor · effector T cell differentiation · Immune evasion · interleukin-2 signalling · IL-2 responsiveness · intratumoural T cell expansion · EP2/EP4 ablation · prostaglandin E2 signalling · early effector T cells · late effector T cells · draining lymph node priming · PGE2-EP2/EP4 axis · tumour elimination · Immunotherapy resistance

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026. https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```