# Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor

*PRI Rank #13 · Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 98 |
| Journal | Cell |
| Year | 2024 |
| DOI | 10.1016/j.cell.2024.04.023 |
| Corresponding authors | Jinjia Zhang |
| Institution | Xiamen University, China |

**Ranking page:** [Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026](https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026)

**Paper link:** [10.1016/j.cell.2024.04.023](https://doi.org/10.1016/j.cell.2024.04.023)

## Topics

Osr2 · biomechanical checkpoint · CD8+ T cell exhaustion · Tumor microenvironment · T cell dysfunction · immune checkpoint · mechanotransduction · Antitumor immunity · T cell activation · Cancer immunology

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026. https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```