# FOXO1 is a master regulator of memory programming in CAR T cells

*PRI Rank #11 · Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026/rank-11*

| Field | Value |
| --- | --- |
| Rank | #11 |
| 18m citations | 104 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07300-8 |
| Corresponding authors | Crystal L. Mackall, Evan W. Weber |
| Institution | Stanford University, United States |

**Ranking page:** [Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026](https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026)

**Paper link:** [10.1038/s41586-024-07300-8](https://doi.org/10.1038/s41586-024-07300-8)

## Topics

FOXO1 · CAR T cells · Memory reprogramming · T cell exhaustion · TCF1 · TCF1 · chimeric antigen receptor · T cell persistence · memory-associated genes · FOXO1 overexpression · Chromatin accessibility · FOXO1-binding motifs · Chronic antigen stimulation · metabolic fitness · Tumor-infiltrating lymphocytes · antitumor activity · FOXO1 inhibition · gene editing · Memory reprogramming · therapeutic T cell states

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited T-cell and B-cell Immunology Papers, Class of 2026. https://pri.pepkio.com/top-papers/t-cell-and-b-cell-immunology/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```