# DEHP-mediated oxidative stress leads to impaired testosterone synthesis in Leydig cells through the cAMP/PKA/SF-1/StAR pathway

*PRI Rank #9 · Topics and Trends in Most Cited Sperm and Testicular Function Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/sperm-and-testicular-function/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 23 |
| Journal | Environmental Pollution |
| Year | 2024 |
| DOI | 10.1016/j.envpol.2024.125503 |
| Corresponding authors | Qiang Dong |
| Institution | Sichuan University, China |

**Ranking page:** [Topics and Trends in Most Cited Sperm and Testicular Function Papers, Class of 2026](https://pri.pepkio.com/top-papers/sperm-and-testicular-function/2026)

**Paper link:** [10.1016/j.envpol.2024.125503](https://doi.org/10.1016/j.envpol.2024.125503)

## Topics

DEHP · oxidative stress · Testosterone production · Leydig cells · cAMP/PKA/SF-1/StAR pathway · cAMP · PKA · SF-1 · StAR · Endocrine disruption · steroidogenesis · phthalate exposure

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Sperm and Testicular Function Papers, Class of 2026. https://pri.pepkio.com/top-papers/sperm-and-testicular-function/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```