# Single-cell RNA sequencing reveals transcriptomic landscape and potential targets for human testicular ageing

*PRI Rank #8 · Topics and Trends in Most Cited Sperm and Testicular Function Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/sperm-and-testicular-function/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 23 |
| Journal | Human Reproduction |
| Year | 2024 |
| DOI | 10.1093/humrep/deae199 |
| Corresponding authors | Chunhua Deng, Andy Peng Xiang |
| Institution | Sun Yat-Sen University, China |

**Ranking page:** [Topics and Trends in Most Cited Sperm and Testicular Function Papers, Class of 2026](https://pri.pepkio.com/top-papers/sperm-and-testicular-function/2026)

**Paper link:** [10.1093/humrep/deae199](https://doi.org/10.1093/humrep/deae199)

## Topics

single-cell RNA sequencing · Testicular aging · spermatogonial stem cells · Leydig cells · base-excision repair pathway · De novo germline mutations · redox homeostasis · Testosterone production · pleiotrophin signalling · Spermatogenesis · CellChat · cell-cell communication · antioxidant treatment · somatic niche cells · cytokine pathways · DNA repair defects · male fertility decline · hypogonadism · germline transcriptomics · stress-related pathways

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Sperm and Testicular Function Papers, Class of 2026. https://pri.pepkio.com/top-papers/sperm-and-testicular-function/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```