# Multiple ageing effects on testicular/epididymal germ cells lead to decreased male fertility in mice

*PRI Rank #19 · Topics and Trends in Most Cited Sperm and Testicular Function Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/sperm-and-testicular-function/2026/rank-19*

| Field | Value |
| --- | --- |
| Rank | #19 |
| 18m citations | 20 |
| Journal | Communications Biology |
| Year | 2024 |
| DOI | 10.1038/s42003-023-05685-2 |
| Corresponding authors | Tsutomu Endo, Masahito Ikawa |
| Institution | Osaka University, Japan |

**Ranking page:** [Topics and Trends in Most Cited Sperm and Testicular Function Papers, Class of 2026](https://pri.pepkio.com/top-papers/sperm-and-testicular-function/2026)

**Paper link:** [10.1038/s42003-023-05685-2](https://doi.org/10.1038/s42003-023-05685-2)

## Topics

male fertility decline · Testicular aging · epididymal ageing · Spermatogenesis · germ cell depletion · sperm release failure · perturbed germ cell associations · spermatogonia proliferation · Sperm morphological abnormalities · sperm motility · Sperm DNA damage · Fertilizing capacity · developmental rates · seminiferous tubules · testosterone levels · mating behavior · in vivo fertility assessment

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Sperm and Testicular Function Papers, Class of 2026. https://pri.pepkio.com/top-papers/sperm-and-testicular-function/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```