# Campylobacter jejuni-derived cytolethal distending toxin promotes colorectal cancer metastasis

*PRI Rank #2 · Topics and Trends in Most Cited Salmonella and Campylobacter epidemiology Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/salmonella-and-campylobacter-epidemiology/2026/rank-2*

| Field | Value |
| --- | --- |
| Rank | #2 |
| 18m citations | 42 |
| Journal | Cell Host & Microbe |
| Year | 2024 |
| DOI | 10.1016/j.chom.2024.11.006 |
| Corresponding authors | Jinlin Huang, Christian Jobin, Ping Lan |
| Institution | Sun Yat-sen University, China |

**Ranking page:** [Topics and Trends in Most Cited Salmonella and Campylobacter epidemiology Papers, Class of 2026](https://pri.pepkio.com/top-papers/salmonella-and-campylobacter-epidemiology/2026)

**Paper link:** [10.1016/j.chom.2024.11.006](https://doi.org/10.1016/j.chom.2024.11.006)

## Topics

Campylobacter jejuni · cytolethal distending toxin (CDT) · CdtB genotoxin · colorectal cancer (CRC) metastasis · JAK2-STAT3-MMP9 signaling pathway · intratumor bacteria · cdtB gene deletion (ΔcdtB) · colonic tumoroids · liver metastasis mouse model · pulmonary metastasis mouse model · bacterial translocation to extraintestinal tumors · C. jejuni-colonized mice · intracellular bacteria in solid tumors · genotoxin-driven tumor progression · MMP9 upregulation · STAT3 activation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Salmonella and Campylobacter epidemiology Papers, Class of 2026. https://pri.pepkio.com/top-papers/salmonella-and-campylobacter-epidemiology/2026. Accessed 2026-07-24.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```